A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/16 (2006.01) A61K 31/437 (2006.01) A61K 31/4409 (2006.01) A61K 31/445 (2006.01) A61P 1/16 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/75 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2369560
Preventives/remedies for liver diseases which contain compounds having an Rho kinase inhibitory activity; and liver astrocyte activation inhibitors. Because of having excellent effects of inhibiting the activation of liver astrocytes, preventing the fibrosis of liver tissues, etc., compounds having an Rho kinase inhibitory activity (for example, (+)- trans-4-(1-aminoethyl)-1-(4- pyridylcarbamoyl) cyclohexane) are useful in preventing and treating various liver diseases such as hepatitis, hepatic fibrosis, liver cirrhosis and liver cancer.
La présente invention concerne des médicaments destinés à soigner et à prévenir les maladies du foie. Ces médicaments contiennent des composés ayant une activité inhibitrice de la Rho kinase, et des inhibiteurs d'activation d'astrocytes du foie. Du fait de leur excellents effets inhibiteurs de l'activation des astrocytes du foie, de leurs effets préventifs sur la cirrhose du foie, etc., les composés ayant une activité inhibitrice de la rho kinase (par exemple (+)-trans-4-(1-aminoéthyle) -1-(pyridylcarbomoyl) cyclohexane) conviennent pour soigner et prévenir diverses maladies du foie telles que l'hépatite, la cirrhose hépatique, la cirrhose du foie et le cancer du foie.
Nakamuta Makoto
Nawata Hajime
Uehata Masayoshi
Fetherstonhaugh & Co.
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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