Agent for prophylaxis and treatment of thromboxane...

A - Human Necessities – 61 – K

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A61K 31/50 (2006.01)

Patent

CA 2183234

An agent for the prophylaxis or treatment of TXA2-mediated diseases, particularly, a TXA2 synthetase inhibitor, which comprises a pyridazinone compound of formula (I), wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof as an active ingredient. The pyridazinone compound (I) and pharmacologically acceptable salts thereof used in the present invention have prophylactic and therapeutic activities against TXA2-mediated diseases, particularly a TXA2 synthetase inhibitory action and are useful as an agent for the prophylaxis or treatment of TXA2-mediated diseases, particularly as TXA2 synthetase inhibitors.

Un agent de prophylaxie ou de traitement des affections à médiation TXA¿2?, en particulier un inhibiteur de la synthétase de la TXA¿2?, contient comme principe actif un composé de pyridazinone correspondant à la formule générale (I) ou l'un de ses sels pharmaceutiquement acceptables. Chaque symbole de ladite formule générale est défini dans la description. Grâce à leur activité prophylactique et thérapeutique dans le cas des affections à médiation TXA¿2?, et en particulier grâce à leur action inhibitrice de la synthétase de la TXA¿2?, le composé de pyridazinone (I), et ceux de ses sels pharmaceutiquement acceptables qui sont utilisés dans la présente invention, constituent un agent utile pour la prophylaxie ou le traitement des affections à médiation TXA¿2?, en particulier pour l'inhibition de la synthétase de la TXA¿2?.

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