A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) C12N 5/0775 (2010.01)
Patent
CA 2722852
The following facts 1) to 3) are found; 1) when a tissue extract which is extracted from an isolated skin graft is administered intravenously, a bone-marrow- derived pluripotent stem cell can be induced in a peripheral blood; 2) the substance which can recruit the bone-marrow-derived pluripotent stem cell contained in the isolated skin graft into the peripheral blood is HMGB1; and 3) HMGB1 which has an activity to recruit the bone-marrow-derived pluripotent stem cell into the peripheral blood can be purified readily from cells in culture.
La présente invention concerne les faits suivants 1) à 3) : 1) lorsqu'un extrait de tissu qui est extrait d'une greffe de peau isolée est administré par voie intraveineuse, une cellule souche pluripotente issue de moelle osseuse peut être induite dans un sang périphérique ; 2) la substance qui peut recruter la cellule souche pluripotente issue de moelle osseuse contenue dans la greffe de peau isolée dans le sang périphérique est HMGB1, et 3) HMGB1 qui a une activité pour recruter la cellule souche pluripotente issue de moelle osseuse dans le sang périphérique peut être purifiée rapidement à partir de cellules en culture.
No affiliations
Genomix Co. Ltd.
Osaka University
Smart & Biggar
LandOfFree
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