C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/3, 150/15.1
C12Q 1/28 (2006.01) C12Q 1/26 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2012604
ABSTRACT OF THE DISCLOSURE The present invention is directed to the elimi- nation of ascorbic acid interference in assay sys- tems, particularly assay systems based upon oxidase- peroxidase coupled reactions. When ascorbic acid is present in a sample, it can act as a reductant thereby interfering with an assay's reagent system. The present invention eliminates this interference by quickly oxidizing any asceorbate thereby preventing ascorbate from acting as an unwanted reductant. The ascorbate is oxidized using a dual oxidant system comprising a water soluble polymer bound to Cu+2 and an organic or inorganic oxidant such as chromate, peroxide, or a N-halo derivative. This invention is surprisingly selective and generally will not itself interfere with the assay's reagent system. Further- more, the present invention is so fast and efficient that it can be incorporated into a convenient format, such as a conventional "dip-and-read" reagent test strip system. KHK:RNC sek:14240 MS-1579
Albarella James P.
Schick Lloyd A.
Yip Meitak T.
Miles Inc.
Osler Hoskin & Harcourt Llp
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