Agent for reducing nephrotoxicity caused by cyclosporin...

Details Agent for reducing nephrotoxicity caused by cyclosporin... Agent for reducing nephrotoxicity caused by cyclosporin...

A - Human Necessities

61

K

167/119

A61K 31/28 (2006.01) C07F 7/30 (2006.01)

Patent

CA 1314211

Abstract The present invention provides (1)an agent for reducing the nephrotoxicity caused by ciclosporin administration, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) Image (I) wherein R1 to R3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O-Y+(Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2)a method for reducing the nephrotoxicity caused by ciclosporin administration, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (1).

580729

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