Agent for regenerating tympanic membrane or external...

A - Human Necessities – 61 – F

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A61F 2/18 (2006.01) A61F 11/00 (2006.01) A61K 9/70 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61L 27/00 (2006.01)

Patent

CA 2729093

Provided is a tympanic membrane or ear canal regeneration agent comprising a combination of a gelatin sponge that carries basic fibroblast growth factor (bFGF) and a covering material. The covering material is used not only to fix the gelatin sponge to the affected portion, but also for the purpose of preventing drying and infections to provide a culturing environment that is favorable for regenerating tissue isolated from the outside. To promote tissue regeneration, the margin of the tympanic membrane or ear canal defect is preferably freshened in advance. 26

La présente invention concerne un agent de régénération dune membrane du tympan ou dun canal auditif externe, qui comprend une combinaison déponge de gélatine portant un facteur de croissance fibroblastique basique (bFGF) et de matériau de couverture. Ledit matériau de couverture est utilisé dans le but de fixer léponge de gélatine sur une zone affectée et dempêcher la dessiccation ou linfection, en vue de produire un environnement adapté à la culture dun tissu régénéré qui est isolé de lextérieur. Dans le but daccélérer la régénération dun tissu, il est préférable de réaliser à lavance une nouvelle zone périphérique dune partie perdue de la membrane du tympan ou du canal auditif externe.

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