C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2610692
An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.
La présente invention concerne un agoniste de EP2 pouvant présenter un effet agoniste de EP3, présentant un effet de régénération et/ou de protection des nerfs, et qui est ainsi utile en tant qu~agent thérapeutique contre une affection du système nerveux périphérique, telle qu~une affection des neurones moteurs inférieurs ou supérieurs, une affection des racines nerveuses, la plexopathie, le syndrome du défilé costoclaviculaire, la neuropathie périphérique, la neurofibromatose et les désordres de la transmission neuromusculaire. L~invention concerne un agoniste de EP2, présentant un effet agoniste de EP3, qui est un agent sans danger et efficace de régénération et/ou de protection des nerfs qui présente une influence réduite sur le système circulatoire.
Kinoshita Akihiro
Matsuya Hidekazu
Ohmoto Kazuyuki
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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