Agent for suppressing bone-resorptive cytokine, containing...

Details Agent for suppressing bone-resorptive cytokine, containing... Agent for suppressing bone-resorptive cytokine, containing...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2316320

An inhibitor of production and/or secretion of IL-1, IL-6 or TNF-.alpha. and a preventive and/or remedy for hypercalcemia accompanying rheumatoid arthritis, asteoarthritis or malignant tumor, characterized by containing dienogest or a solvate thereof as the active ingredient, while utilizing novel cytokine production inhibitory activities of dienogest or a solvate thereof.

L'invention concerne un inhibiteur de production et/ou de sécrétion d'IL-1, IL-6 ou TNF-.alpha., ainsi qu'un agent préventif et/ou un remède contre l'hypercalcémie accompagnant la polyarthrite rhumatoïde, l'arthrose ou les tumeurs malignes, caractérisé en ce qu'il contient du diénogest ou un solvate de celui-ci en tant que principe actif, tout en utilisant les nouvelles activités inhibitrices de la production de cytokine du diénogest ou d'un solvate de celui-ci.

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