C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
260/279, 260/317
C12Q 1/04 (2006.01) C07D 209/36 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 1130801
ARSTRACT OF THE DISCLOSURE A diagnostic agent for the detection of proteolytic enzymes, comprises an absorbent support, a film layer, a powder mixture, a lyophilisate, a solution or a reagent tablet, containing at least one chromogen and an appropriate buffer substance, wherein the chromogen used is an indoxyl- and/or thioindoxyl-amino acid ester and/or peptide ester of the formula (I):- Image (I) wherein R1, R2, R3 and R4, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, lower alkoxy. aryl. aralkyl, aralkoxy, hydroxyl, carboxy, carboxy lower alkoxy. aralkoxycarbonyl, aralkyloxycarbonyl lower alkoxy, nitro or lower acylamino radicals. whereby two adjacent substituents can also represent an optionally halogenated fused benzene ring, X is a sulphur atom or an imino group optionally sub- stituted by a lower alkyl. aryl. aralkyl or acyl radical. A is an amino acid or peptide residue and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom new compounds of formula (I) are also provided and processes for their preparation: furthermore. methods of use of the compounds of formula (I) for the production of diagnostic agents and the detection of proteolytic enzymes are disclosed.
341299
Berger Dieter
Braun Franz
Guthlein Werner
Kuhr Manfred
Werner Wolfgang
Boehringer Mannheim G.m.b.h.
Sherman
LandOfFree
Agent for the detection of leukocytes in body fluids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agent for the detection of leukocytes in body fluids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agent for the detection of leukocytes in body fluids will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-771772