A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4725 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 9/06 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2617519
Disclosed is a therapeutic agent for atrial fibrillation comprising an If current inhibitor, particularly (-)-N-[2-[(R)-3-(6,7-dimethoxy-1,2,3,4- tetrahydro- isoquinoline-2-carbonyl)piperidino]ethyl]-4-fluorobenzamide monophosphate, as an active ingredient. This active ingredient has more preferred properties for use as a therapeutic agent for atrial fibrillation compared to verapamil (a Ca antagonist) and atenolol (a .beta.-blocker) which have been conventionally used as the therapeutic agents for atrial fibrillation.
La présente invention concerne un agent thérapeutique de la fibrillation auriculaire comportant un inhibiteur courant I<SUB>f</SUB> , particulièrement un monosphosphate (-)-N-[2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydro- isoquinoline-2-carbonyl)piperidino]ethyl]-4-fluorobenzamide comme ingrédient actif. Cet ingrédient actif comporte des propriétés préférées à utiliser comme agent thérapeutique pour la fibrillation auriculaire comparé au vérapamil (un antagoniste Ca) et à l'aténolol (un bloqueur ß) qui ont été utilisés conventionnellement comme agent thérapeutique de la fibrillation auriculaire.
Masuda Noriyuki
Taniguchi Keiichi
Wada Koichi
Astellas Pharma Inc.
Dennison Associates
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