A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/166 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2404775
Preventive and/or therapeutic drugs for diseases due to stenotic lesions of blood vessel, which contain as the active ingredient hydroxamic acid derivatives of the general formula (I) exhibiting matrix metalloprotease inhibiting activity or nontoxic salts thereof: wherein R1 is hydrogen, C1-8 alkyl, or C1-8 alkyl substituted with OR2, R2 being hydrogen, C1-8 alkyl, benzyl, or C1-8 alkyl substituted with C1-8 alkoxy.
L'invention concerne des médicaments préventifs et/ou thérapeutiques pour le traitement de maladies associées aux lésions sténosées de vaisseaux sanguins. Lesdits médicaments contiennent comme principe actif des dérivés d'acide hydroxamique de formule générale (I), présentant une activité inhibitrice de métalloprotéase matricielle, ou des sels non toxiques desdits dérivés. Dans ladite formule, R?1¿ représente hydrogène, C¿1-8 ?alkyle ou C¿1-8 ?alkyle substitué par OR?2¿, R?2¿ représentant hydrogène, C¿1-8 ?alkyle, benzyle ou C¿1-8 ?alkyle substitué par C¿1-8? alcoxyle.
Matsuno Hiroyuki
Uematsu Toshihiko
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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