Agent for treating disorders from cerebral neuro-degeneration

Details Agent for treating disorders from cerebral neuro-degeneration Agent for treating disorders from cerebral neuro-degeneration

A - Human Necessities

61

K

167/208, 167/244

A61K 31/395 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 311/94 (2006.01)

Patent

CA 2037188

ABSTRACT AGENT FOR TREATING DISORDERS FROM CEREBRAL NEURO-DEGENERATION A therapeutic agent for alleviating disorders caused by nerve cell degeneration in the brain which contains a cyclopropachromen derivative represented by the following general formula (I): (I) Image wherein n is an integer of from 2 to 5; the carbon atom in the -(CH2)n- moiety may be option- ally substituted with a methyl group or a hydroxyl group; Rl and R2 independentlY represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; or alternatively R1 and R2 form together with the nitrogen atom to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N- alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R1 and R2 form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group; Al and A2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an optionally substituted alkoxy group, an acyloxy group, a carbamyloxy group or an optionally substituted carboxyl group; and Bl and B2 independently represent a hydrogen atom, a halogen atom, a nitro group, a cyano group, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an optionally substituted carboxyl group; or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutical carrier or adjuvant.

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