Agent for treating or preventing digestive ulcer

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/426 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) A61K 31/455 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2643272

It is intended to provide a remedy or a preventive for digestive ulcer being efficacious for ulcer in the small intestine, etc., on which the existing gastric antisecretory agents such as proton pump inhibitors exert no effect, and superior in efficaciousness and safety to Allopurinol. A medicinal composition, which contains a non-purine xanthine oxidase inhibitor as the active ingredient, is useful as a remedy or a preventive for ulceration in the digestive tract caused by gastric acid, pepsin, stress, Helicobacter pylori, the attack by NSAID, etc. This medicinal composition is particularly useful as a nonconventional remedy for ulcer because of being efficacious against ulcer in the small intestine on which the existing remedies for gastric and duodenal ulcer inhibiting gastric acid secretion such as proton pump inhibitors exert no effect.

La présente invention concerne un remède ou un agent préventif contre l'ulcère digestif qui est efficace contre un ulcère situé dans l'intestin grêle, etc., sur lequel les agents anti-sécrétoires gastriques existants tels que les inhibiteurs de la pompe à protons n'exercent aucun effet, et qui possède des propriétés d'efficacité et de sécurité supérieures à celles de l'Allopurinol. Une composition médicinale qui contient en tant que matière active un inhibiteur de la xanthine oxydase autre qu'une purine est utilisable en tant que remède ou agent préventif contre l'ulcération des voies digestives causées par l'acide gastrique, la pepsine, le stress, Helicobacter pylori, une attaque par des anti-inflammatoires non stéroïdiens, etc. Cette composition médicinale est particulièrement utile en tant que remède non conventionnel contre l'ulcère parce qu'elle est efficace contre les ulcères de l'intestin grêle sur lesquels les remèdes existants contre les ulcères de l'estomac et du duodénum inhibant la sécrétion de l'acide gastrique, tels que les inhibiteurs de la pompe à protons, n'exercent aucun effet.

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