Agent for treatment of arthritic disease

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/30 (2006.01) A61K 47/48 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2364451

The present invention provides an agent for treatment of arthritic diseases such as rheumatoid arthritis that has for its active ingredient a complex of hyaluronic acid and zinc. This complex synergistically inhibits proliferation of synovial cells and suppresses matrix metalloproteinase MMP-9, which is produced by synovial cells, as compared with its constituents, hyaluronic acid and zinc, alone.

L'invention concerne des médicaments contre les affections articulaires telles que la polyarthrite rhumatoïde, qui renferment, comme ingrédient actif, un complexe (associé) d'acide hyaluronique avec du zinc. Comparé avec l'acide hyaluronique et le zinc (c'est-à-dire leurs constituants), ce complexe inhibe de manière synergique la prolifération des cellules de la membrane synoviale, régulant ainsi la production d'une enzyme MMP-9 histoclastique produite par lesdites cellules de la membrane synoviale.

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