Agent inducing increase in bone mass

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/663 (2006.01) A61K 31/5025 (2006.01) A61K 31/662 (2006.01) A61K 45/00 (2006.01) A61P 1/02 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2529558

In metabolic bone diseases such as osteoporosis, it is frequently observed that bone strength is lowered due to a decrease in bone mass and, in its turn, there arise pain such as lumbar pain and bone fracture. Thus, it is urgently required to design a drug capable of controlling the entire bone metabolism to thereby increase bone mass and elevate bone strength. A medicinal composition or combination containing a nonpeptidic osteoblast differentiation promoting compound originating in a nonliving material and bisphosphonate having an effect of inhibiting bone resorption is useful as an agent inducing an increase in bone mass which is capable of controlling bone metabolism to thereby increase bone mass and/or elevate bone strength.

Dans des maladies métaboliques de l'os telles que l'ostéoporose, on observe souvent une réduction de la résistance de l'os due à une diminution dans la masse osseuse et, par la suite, il se produit une douleur telle qu'une douleur lombaire et une fracture de l'os. Ainsi, la conception d'un médicament capable de contrôle total du métabolisme de l'os est impérativement nécessaire en vue de la croissance de la masse osseuse et de l'amélioration de la résistance de l'os. La présente invention a trait à une composition ou combinaison médicamenteuse contenant un composé favorisant la différenciation ostéoblastique non peptidique dérivé d'un matériau inorganique et de diphosphonate présentant un effet d'inhibition de la résorption osseuse utile en tant qu'agent induisant une croissance dans la masse osseuse capable du contrôle du métabolisme de l'os pour augmenter la masse osseuse et/ou améliorer la résistance de l'os.

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