C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/745 (2006.01) A61K 38/36 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2190642
Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.
Des analogues de facteurs sanguins qui sont transitoirement inactifs peuvent être utilisés dans le traitement de maladies caractérisées par la thrombose. En outre, des formes modifiées de facteurs sanguins activés qui génèrent le facteur sanguin actif dans le sérum mais ont des demi-vies prolongées peuvent être utilisées pour traiter des hémophylies. Ces formes modifiées de facteur sanguin peuvent être des formes acylées qui sont lentement désacylées in vivo.
Sinha Uma
Wolf David L.
Cor Therapeutics Inc.
Deeth Williams Wall Llp
Millennium Pharmaceuticals Inc.
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