Agents and methods for enhancing bone formation

A - Human Necessities – 61 – K

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Details

A61K 31/56 (2006.01) A61K 38/18 (2006.01) A61K 38/29 (2006.01) A61K 38/30 (2006.01)

Patent

CA 2495882

The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders, local injections of oxysterols or cells (206) and implants (202) having agents or cells (203) to facilitate bone repair.

Cette invention se rapporte à des agents et à des procédés servant à induire une différenciation cellulaire ostéoblastique, ainsi qu'à l'utilisation de ces agents et de ces procédés pour traiter des patients, afin de préserver la masse osseuse et/ou stimuler la formation osseuse et/ou la réparation osseuse. A titre d'exemple, ces agents sont les oxystérols, seuls ou associés à des oxystérols particuliers, ou d'autres agents connus pour favoriser la formation osseuse. Cette invention concerne en outre des médicaments contenant des oxystérols pour le traitement des affections osseuses, des injections locales d'oxystérols ou de cellules (206) et des implants (202) comportant des agents ou des cellules (203) destinés à faciliter la réparation osseuse.

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