C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/18 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/335 (2006.01) A61K 31/357 (2006.01) A61P 39/04 (2006.01) A61P 39/06 (2006.01) C07C 229/76 (2006.01) C07D 273/08 (2006.01) C07D 311/58 (2006.01) C07D 323/00 (2006.01)
Patent
CA 2487273
The invention provides a method for preventing or reducing the effects of oxidative stress on a substrate. The method includes the step of treating the substrate with a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R1 is one or more substituents selected from -H, - alkyl, -alkoxy, -aryl, -aryloxy, -halogen, -amino (mono-, di- and tri- substituted), -alkylthio, -NO2, -COOH, -COOAlkyl, -CO-alkyl, -CN; R2 is one or more substituents selected from -H, -alkyl, -(CH2CH2O)n-R5, a sugar moiety; R3 is -H, -alkyl, -aryl, -alkylOR6 , -alkylC(O)R6; R5 is selected from -H, - alkyl, -aryl; and R4 and R6 are independently selected from -OH, -O-alkyl, -O- polyalkyleneoxy, -O-aryl, -OC(O)O-alkyl, -S-alkyl and -amino.
L'invention concerne un procédé de prévention et de réduction des effets du stress oxydatif sur un substrat. Ledit procédé comprend le traitement du substrat à l'aide d'un composé de formule (I) ou d'un de ses sels pharmaceutiquement acceptable. Dans cette formule, R?1¿ représente un ou plusieurs substituants choisis parmi -H, -alkyle, -alcoxy, -aryle, -aryloxy, -halogène, -amino (mono-, di- and tri-substitués), -alkylthio, -NO¿2?, -COOH, -COOalkyle, -CO-alkyle, -CN ; R?2¿ représente un ou plusieurs substituants choisis parmi -H, -alkyle, -(CH¿2?CH¿2?O)n- ; R?5¿ représente une fraction de sucre ; R?3¿ représente -H, -alkyle, -aryle, -alkylOR?6¿, -alkylC(O)R?6 ¿; R?5¿ est choisi parmi -H, -alkyle, -aryle ; R?4¿ et R?6¿ sont choisis, indépendamment l'un de l'autre, parmi -OH, -O-alkyle, -O-polyalkylèneoxy, -O-aryle, -OC(O)O-alkyle, -S-alkyle et -amino.
Beart Philip Mark
Cheema Surindar Singh
Cheung Nam Sang
Langford Steven
Macfarlane Katherine Jane
Monash University
Sim & Mcburney
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