Agents and methods for treating pain

Details Agents and methods for treating pain Agents and methods for treating pain

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2433332

Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent are disclosed. The agent may include a clostridial neurotoxin, a fragment or a derivative thereof, attached to a targeting component, wherein the targeting component is selected form a group consisting of compounds which selectively binds at the alpha-2B or alpha-2B/alpha-2C adrenergic receptor subtype(s) as compared to other binding sites, for example, the alpha-2A adrenergic receptor subtype.

L'invention concerne des agents de traitement de la douleur, des procédés de production de ces agents ainsi que des méthodes destinées au traitement de la douleur par administration à un patient d'une dose thérapeutiquement efficace d'un agent de ce type. L'agent peut comprendre une neurotoxine clostridiale, voire un fragment ou un dérivé correspondant, fixée sur un composant de ciblage, ce composant de ciblage étant sélectionné dans un groupe constitué par des composés se liant sélectivement au niveau du/des sous-type(s) du récepteur adrénergique alpha-2B ou alpha-2B/alpha-2C, par comparaison avec d'autres sites de liaison tels que le sous-type du récepteur adrénergique alpha-2A.

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