Agents and methods for treatment of cancer

Details Agents and methods for treatment of cancer Agents and methods for treatment of cancer

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/10 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/275 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/382 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/428 (2006.01) A61K 31/435 (2006.01) A61K 31/50 (2006.01) A61K 31/60 (2006.01) A61K 31/66 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2441394

Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxygenase-2 in a pharmaceutical composition. The agents and methods are used for chemoprevention and treatment of neoplasia including colorectal cancer and other cancers affecting epithelial cells throughout the body. The agents can also be used to treat the fibrosis that occurs with radiation therapy, as well as adenomatous polyps, including those with familial adenomatous polyposis (FAP).

La présente invention concerne des agents et des procédés pour la chimio-prévention et le traitement de la néoplasie, les agents comprenant un inhibiteur sélectif de la synthase inductible du monoxyde d'azote et une combinaison d'un inhibiteur de la synthase inductible du monoxyde d'azote et un inhibiteur de la cyclo-oxygénase-2 dans une composition pharmaceutique. Les agents et les procédés sont utilisés pour la chimio-prévention et le traitement de la néoplasie y compris le cancer colorectal et d'autre cancers affectant les cellules épithéliales dans le corps. Les agents peuvent également être utilisés pour traiter la fibrose qui apparaît avec la radiothérapie, ainsi que les polypes adénomateux, y compris ceux avec la polypose rectocolique.

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