Agents and methods for treatment of pain

Details Agents and methods for treatment of pain Agents and methods for treatment of pain

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 35/76 (2006.01) A61P 29/02 (2006.01)

Patent

CA 2739416

The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat- NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.

La présente invention porte sur des agents utiles pour le traitement de la douleur. Un agent cité en exemple comprend ou est constitué dune partie d'une protéine Tat rétrovirale. Un tel agent est le peptide Tat-NR2B9c. Ce peptide a été précédemment décrit en tant qu'agent d'inhibition des effets néfastes d'un accident vasculaire cérébral et d'états similaires par inhibition des interactions de PSD95 avec les récepteurs NMDA et/ou NOS. La présente invention apporte des données montrant que le peptide Tat-NR2B9c est efficace pour soulager la douleur. On peut obtenir le soulagement de la douleur à une dose de peptide inférieure à la dose requise pour inhiber les interactions de PSD-95 avec un récepteur NMDAR ou NOS.

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