C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2595440
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.
L'invention concerne une méthode destinée à inverser ou à prévenir la résistance d'une cellule cible à un agoniste des récepteurs de mort. L'invention concerne également des méthodes de criblage de biomarqueurs de résistance, et de contrôle de la résistance aux agonistes des récepteurs de mort. L'invention concerne également des méthodes destinées à induire l'apoptose de manière sélective dans une cellule cible, ainsi que des méthodes de traitement de patients souffrant de cancer ou de maladies auto-immunes ou inflammatoires, consistant à administrer des compositions selon l'invention. L'invention concerne encore des compositions contenant des agents modulant des protéines contenant des CARD.
Kimberly Robert P.
Zhou Tong
Marks & Clerk
The Uab Research Foundation
LandOfFree
Agents and methods related to reducing resistance to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agents and methods related to reducing resistance to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agents and methods related to reducing resistance to... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1458656