Agents capable of downregulating an msf-a-dependent...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 16/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2576293

Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.

La présente invention concerne des méthodes et des compositions pharmaceutiques permettant de traiter un cancer ou une ischémie aiguë. L'invention concerne également des méthodes permettant d'identifier des agents capables de prévenir la formation d'un complexe protéique MSF-A-HIF-1alpha, ou de dissocier ce complexe. L'invention concerne également des méthodes permettant d'établir le pronostic d'un individu atteint d'un cancer par identification de la présence ou de l'absence d'un tel complexe protéique.

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