Agents comprising midkine or its inhibitor as active ingredient

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 31/727 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2296409

Midkine (MK), which is a retinoic acid-inducible heparin-binding growth factor, enhances neutrophilic migration and exists in an inflammatory state at a high concentration. The midkine or its inhibitors can be used for treating neutrophilic functional disorders or inflammatory diseases.

On décrit des médicaments servant à traiter des troubles fonctionnels ou des maladies inflammatoires neutrophiles, qui contiennent midkine (MK) comme principe actif, laquelle est un facteur de croissance rétinoïque de fixation à l'héparine pouvant être mobilisé par l'acide. On a constaté que ce facteur de croissance pouvait améliorer la migration neutrophile, et existait en forte concentration à l'état inflammatoire. On décrit en outre des inhibiteurs desdits médicaments.

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