Agents for blood-brain barrier delivery

Details Agents for blood-brain barrier delivery Agents for blood-brain barrier delivery

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 25/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12N 15/79 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2661042

The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier, in some embodiments in both directions, while allowing their activity once across the barrier to remain substantially intact The agents are transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems. In some embodiments the agents are therapeutic, diagnostic, or research agents.

La présente invention concerne des compositions, des procédés, et des trousses permettant d'accroître le transport d'agents au travers de la barrière hémato-encéphalique, dans certains modes de réalisation dans les deux directions, tout en assurant leur activité une fois au travers de la barrière, afin qu'ils demeurent sensiblement intacts. Les agents sont transportés à travers la barrière hémato-encéphalique par un ou plusieurs systèmes de transport médiés par des récepteurs endogènes. Dans certains modes de réalisation, les agents sont des agents thérapeutiques, diagnostiques, ou de recherche.

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