Agents for intravitreal administration to treat or prevent...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/70 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/495 (2006.01) A61K 31/60 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2366050

Methods and preparations for treating disorders of the eye and/or causing posterior vitreous disconnection or disinsertion. Preparations containing (a) urea, (b) urea derivatives (e.g., hydroxyurea, thiourea), (c) a non-steroidal anti-inflamatory agent, (d) antimetabolites, (e) urea, urea derivatives, non- enzymatic proteins, nucleosides, nucleotides and their derivatives (e.g., adenine, adenosine, cytosine, cytadine, guanine, guanitadine, guanidinium, thymidine, thimitadine, uradine, uracil, cystine), uric acid, calcium acetal salicylate, ammonium sulfate or other compound capable of causing non- enzymatic dissolution of the hyaloid membrane or (e) any of the possible combinations thereof, are administered to the eye in therapeutically effective amounts.

L'invention concerne des méthodes et des préparations permettant de traiter des troubles oculaires et/ou de procéder à une désinsertion ou à un détachement vitréen postérieur. On administre à l'oeil des quantités thérapeutiquement efficaces de préparations contenant (a) de l'urée (b) des dérivés d'urée (notamment, l'hydroxyurée, la thiourée), (c) un anti-inflammatoire non stéroïdien, (d) des antimétabolites, (e) de l'urée, des dérivés d'urée, des protéines non enzymatiques, des nucléosides, des nucléotides et leurs dérivés (notamment, l'adénine, l'adénosine, la cytosine, la cytadine, la guanine, la guanitadine, le guanidinium, le thymidine, le thimitadine, l'uradine, l'uracil, la cystine), de l'acide urique, du sylicylate d'acétal de calcium, du sulfate d'ammonium ou un autre composé capable d'entraîner une dissolution non enzymatique de la membrane hyaloïde ou (e) n'importe quelle combinaison possible des composés mentionnés.

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