Agents for protection from neointimal formation in grafts...

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01) A61K 31/711 (2006.01) A61K 45/00 (2006.01) A61P 9/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2500367

It is intended to provide a method of inhibiting neointimal thickening in a graft by using a decoy against NF.kappa.B and thus regulating (inhibiting) the transcription activated by NF.kappa.B. Also, an agent containing a decoy of NF.kappa.B which protects a vascular graft against intimal thickening.

L'invention concerne un procédé d'inhibition de l'épaississement de la néo-intima dans une greffe en utilisant un piège contre NFkB et en régulant ainsi (inhibition) la transcription activée par NFkB. L'invention concerne également un agent contenant un piège de NFkB protégeant une greffe vasculaire contre un épaississement de l'intima.

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