Agents for regulating the activity of interferon-producing...

Details Agents for regulating the activity of interferon-producing... Agents for regulating the activity of interferon-producing...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 45/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2570602

An activity regulator for interferon producing cells (IPC), comprising an antibody binding to BST2 and/or its homologue as an active ingredient; and a method of regulating the activity of IPC wherein use is made of this antibody. By virtue of these, IPC~s capacity for interferon (IFN) production and cell quantity can be directly controlled. Further, there is provided use of BST2 and/or its homologue as an IPC activation marker. Screening of a compound capable of regulating the activation of IPC can be realized by the use of the IPC activation marker.

Régulateur d'activité pour des cellules produisant de l'interféron (IPC), comprenant un anticorps liant BST2 et/ou son homologue comme ingrédient actif ; et procédé de régulation de l'activité d'IPC, ledit procédé comprenant d'utiliser cet anticorps. Grâce à ceci, on peut contrôler directement la capacité des IPC à produire des interférons (IFN) et la quantité de cellules. En outre, il est fourni l'utilisation de BST2 ou de son homologue comme marqueur d'activation d'IPC. On peut réaliser la recherche par criblage d'un composé capable de réguler l'activation d'IPC grâce à l'utilisation du marqueur d'activation d'IPC.

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