A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/513 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 1/08 (2006.01) A61P 1/12 (2006.01) A61P 3/00 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2331737
The present invention provides an agent for alleviating side effects caused by use of an anti-tumor agent, which contains 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidi nedione (1) represented by formula (1): (see formula I) or a pharmaceutically acceptable salt thereof. The 5-chloro -6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof exhibit an inflammatory-suppressing action in the digestive tract and advantageously alleviate diarrhea and loss of body weight concomitant with administration of a chemical for treating cancer without suppressing the anti-tumor effect. Thus, the compounds of the present invention are of great value as agents for alleviating side effects caused by use of an anti-tumor agent, which enable not only the chemotherapy to be continuedly carried out, but also the body exhaustion to be effectively prevented.
Cette invention concerne des agents atténuant les effets secondaires d'agents antitumoraux. Le principe actif de ces agents atténuateurs est 5-chloro-6-(2-imminopyrrolidine-1-yl)méthyl-2, 4(1H, 3H)-pyriminedione représenté par la formule (1) ou des sels de ce composé acceptables au plan pharmaceutique. Le 5-chloro-6-(2-imminopyrrolidine-1-yl)méthyl-2, 4(1H, 3H)-pyriminedione (1) et ses sels offrent l'avantage d'inhiber l'inflammation de l'appareil digestif provoquée par l'administration d'agents antitumoraux et donc d'atténuer la diarrhées ou la perte de poids associée associée à la chimiothérapie du cancer sans réduire l'effet antitumoral. Au vu de ces caractéristiques, ces agents conviennent particulièrement bien pour atténuer les effets secondaires, ce qui permet de ne pas interrompre la chimiothérapie et d'empêcher l'épuisement physique du malade.
Fukushima Masakazu
Suzuki Norihiko
Yamamoto Noriyuki
Gowling Lafleur Henderson Llp
Taiho Pharmaceutical Co. Ltd.
LandOfFree
Agents for relieving side effects caused by use of an... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agents for relieving side effects caused by use of an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agents for relieving side effects caused by use of an... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1462415