Agents for the diagnosis of vascular diseases

Details Agents for the diagnosis of vascular diseases Agents for the diagnosis of vascular diseases

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) G01N 33/532 (2006.01)

Patent

CA 2113245

ABSTRACT OF THE DISCLOSURE The present invention relates to metal complexes and me- tal complex conjugates of endothelines, endotheline de- rivatives, endotheline partial sequences, endotheline analogues, or endotheline antagonists, iodinated endo- theline derivatives, endotheline partial sequences, endo- theline analogues, or endotheline antagonists, and means containing such compounds, their preparation as diagnostic agents, as well as processes for the manufactu- ring of such compounds and agents. In vivo applicable metal complexes and metal complex con- jugates of endothelines, endotheline derivatives, endotheline partial sequences, endotheline analogues, or endotheline antagonists as well as iodinated endotheline derivatives, endotheline partial sequences, endotheline analogues, or endotheline antagonists are preferably used for the non-invasive imaging of vascular diseases.

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