Agents for treating diseases caused by nonsense mutation

Details Agents for treating diseases caused by nonsense mutation Agents for treating diseases caused by nonsense mutation

A - Human Necessities

61

K

A61K 31/175 (2006.01) A61K 31/198 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2449950

Compositions for treating diseases caused by nonsense mutation which contain dipeptide-type antibiotics such as negamycin represented by the following fomrula (1). These dipeptide-type antibiotics can induce the expression of a protein having misread the nonsense mutation and matured without bringing about any severe side effects as in the case of aminoglycoside-type antibiotics such as gentamycin.

L'invention concerne des compositions destinées au traitement de maladies provoquées par une mutation non-sens, contenant des antibiotiques de type dipeptide, tels que la négamycine représentée par la formule (1). Ces antibiotiques de type dipeptide peuvent induire l'expression d'une protéine ayant lu de façon erronée la mutation non-sens et développée sans entraîner de quelconques effets secondaires comme dans le cas d'antibiotiques de type aminoglycoside, tels que la gentamycine (1).

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