Agents useful for reducing amyloid precursor protein and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/5365 (2006.01) A61P 25/28 (2006.01) C07C 217/58 (2006.01) C07C 233/22 (2006.01) C07C 265/12 (2006.01) C07D 209/16 (2006.01) C07D 209/34 (2006.01) C07D 277/82 (2006.01) C07D 487/08 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2465534

The present invention provides compounds and methods of administering compounds to a subject taht can reduce .beta.APP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce .beta.APP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease .beta.APP production.

La présente invention se rapporte à des composés et à des procédés d'administration de ces composés à un sujet aux fins de la réduction de la production de la beta APP, lesdits composés ne présentant pas d'effet toxique pour une large gamme de doses absorbées. La présente invention se rapporte également à des composés non carbamate ainsi qu'à des procédés d'administration de tels composés à un sujet aux fins de la réduction de la production de la beta APP, lesdits composés présentant pas d'effet toxique pour une large gamme de doses absorbées. Il a été démontré que ces composés non carbamate, racémiques ou énantiomériquement purs, peuvent être utilisés pour réduire la production de la beta APP.

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