C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2296766
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
L'invention concerne la famille de métalloprotéases décomposant l'aggrecan (métalloprotéases ADMP) qui manifestent la capacité de cliver la protéine noyau de l'aggrecan entre les résidus d'acides aminés Glu<373>-Ala<374>. L'invention englobe les acides nucléiques codant pour ces enzymes, les procédés de fabrication de métalloprotéases ADMP recombinantes, les compositions comprenant ces enzymes et l'utilisation de ces enzymes dans la conception de nouveaux inhibiteurs, destinés à des fins thérapeutiques dans le cas de maladies entraînant la décomposition du cartilage induite par l'aggrecanase ou d'autres maladies liées à l'aggrecanase.
Arner Elizabeth C.
Burn Timothy C.
Copeland Robert A.
Decicco Carl P.
Liu Ruiqin
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Du Pont Pharmaceuticals Company
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