Aggrecanase molecules

Details Aggrecanase molecules Aggrecanase molecules

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2451374

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized bythe degradation of aggrecan are also disclosed.

L'invention a trait à de nouvelles protéines d'aggrécanase et aux séquences nucléotidiques qui les codent, ainsi qu'à leurs procédés de production. L'invention concerne également des procédés d'élaboration d'inhibiteurs des aggrécanases et d'anticorps dirigés contre ces dernière, destinés au traitement des états caractérisés par la dégradation de l'aggrécane.

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