Aggrecanase molecules

Details Aggrecanase molecules Aggrecanase molecules

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/22 (2006.01) C12N 9/64 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2474908

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

L'invention concerne de nouvelles protéines aggrécanases et les séquences nucléotidiques les codant, ainsi que des procédés pour leur production. Elle concerne également des méthodes pour identifier et développer des inhibiteurs des aggrécanases ainsi que des anticorps dirigés contre ces enzymes pour le traitement d'états caractérisés par une dégradation de l'aggrécane.

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