C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) A61K 47/48 (2006.01) C12N 9/06 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2398679
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
L'invention concerne une protéine recombinante naturelle, notamment une mutéine d'urate oxidase porcine (uricase), sensiblement exempte de gros agrégats, qui peut être rendue sensiblement non immunogène par conjugaison avec un nombre suffisamment petit de brins de polymère, de sorte que la bioactivité de la protéine soit considérablement conservée dans le conjugué. De tels conjugués sont habituellement très peu adaptés au traitement d'affections chroniques parce qu'ils sont moins suceptibles d'induire la formation d'anticorps et/ou un dégagement accéléré qu'il n'est le cas avec des conjugués similaires obtenus à partir de préparations protéiques contenant des traces de gros agrégats.
Hershfield Michael S.
Kelly Susan J.
Saifer Mark G. P.
Sherman Merry R.
Williams L. David
Barrigar Intellectual Property Law
Duke University
Mountain View Pharmaceuticals Inc.
LandOfFree
Aggregate-free urate oxidase for preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aggregate-free urate oxidase for preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aggregate-free urate oxidase for preparation of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2040506