Aggregates of human insulin derivatives

Details Aggregates of human insulin derivatives Aggregates of human insulin derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 5/48 (2006.01)

Patent

CA 2308705

Water-soluble aggregates of derivatives of human insulin which have a protracted profile of action are disclosed. A new mechanism is involved in prolonging the action of the soluble insulin derivatives. This mechanism is based on the partly or fully formation of soluble aggregated forms of the derivatives, featuring a size larger than aldolase (Mw = 158 kDa) in a defined gel filtration system.

L'invention se rapporte à des agrégats de dérivés de l'insuline humaine qui possèdent un profil prolongé d'activité. Le prolongement de l'activité de ces dérivés d'insuline solubles est lié à un nouveau mécanisme fondé sur la formation partielle ou totale de formes agrégées solubles de ces dérivés, présentant une taille supérieure à celle de l'aldolase (poids moléculaire = 158 kDa), dans un système de filtration sur gel défini.

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