Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof

Details Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2528551

The invention relates to aglycosyl anti-CD154 antibodies or antibody derivatives, characterized by a modification at the conserved N-linked site in the CH2 domains of the Fc portion of said antibody. The invention also relates to the treatment of immune response related diseases and inhibition of unwanted immune response with such aglycosylated anti-CD154 antibodies or antibody derivatives thereof.

L'invention concerne des anticorps d'aglycosyle anti-CD154 ou des dérivés d'anticorps, caractérisés par une modification au niveau d'un site à liaison N conservé dans les domaines C<SB>H2</SB> de la partie Fc de cet anticorps. L'invention concerne également le traitement de maladies liées à la réponse immunitaire et l'inhibition de réponses immunitaires non souhaitées avec ces anticorps aglycosylés anti-CD154 ou avec des dérivés de ces anticorps.

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