Agomelatine hydrohalide complex and preparation method thereof

Details Agomelatine hydrohalide complex and preparation method thereof Agomelatine hydrohalide complex and preparation method thereof

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 233/18 (2006.01)

Patent

CA 2753449

Agomelatine hydrohalide complex and preparation method thereof are disclosed. Compared with agomelatine, agomelatine hydrohalide complex obtained by the present method has improved solubility, and is suitable for application need of preparation of finished products of drugs. Furthermore, the product has good stability and high purity. The preparation process is simple and convenient, and the product with high purity can be obtained without special operations.

La présente invention concerne un complexe d'hydrohalogénure d'agomélatine et un procédé de préparation de celui-ci. Comparé à l'agomélatine, un complexe d'hydrohalogénure d'agomélatine obtenu par le présent procédé a une solubilité améliorée, et est adapté à l'application nécessaire de préparation de produits finis de médicaments. De plus, le produit a une bonne stabilité et une pureté élevée. Le procédé de préparation est simple et commode et le produit ayant une pureté élevé peut être obtenu sans opérations spéciales.

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