Agonist anti-trk-c monoclonal antibodies

Details Agonist anti-trk-c monoclonal antibodies Agonist anti-trk-c monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2412494

The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.

L'invention concerne des anticorps monoclonaux anti-trkC agonistes qui imitent certaines activités biologiques du NT-3, le ligand d'origine du trkC. L'invention concerne également l'utilisation de ces anticorps dans la prévention et/ou le traitement de la dégénérescence cellulaire, y compris les dommages neuraux associés à une blessure aiguë du système neuronal et des affections neurodégénerescentes chroniques comprenant une neuropathie périphérique.

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