Agonist antibodies against the flk2/flt3 receptor and uses...

Details Agonist antibodies against the flk2/flt3 receptor and uses... Agonist antibodies against the flk2/flt3 receptor and uses...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/26 (2006.01)

Patent

CA 2185211

Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a homorrhage, for example.

Anticorps agonistes se liant au domaine extracelullaire du récepteur flk2/flt3 et activant ainsi son domaine de kinase intracellulaire. Les anticorps étiquetés sont utiles comme agents diagnostique pour dépister la présence du récepteur flk2/flt3 dans des cellules hématopoïétiques primitives, par exemple. Ces anticorps peuvent déclencher une prolifération et/ou une différentiation des cellules hématopoïétiques primitives et stimuler ainsi la repopulation de lignées de globules sanguins matures chez un patient ayant subi une chimiothérapie ou une radiothérapie ou bien une transplantation de moelle osseuse. Ces anticorps sont en outre utiles pour traiter des patients ayant souffert d'une diminution du nombre des globules sanguins en conséquence d'un état pathologique ou d'une hémorragie, par exemple.

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