Agonist antibodies to the thrombopoietin receptor, and their...

Details Agonist antibodies to the thrombopoietin receptor, and their... Agonist antibodies to the thrombopoietin receptor, and their...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301964

Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.

Cette invention concerne diverses formes d'anticorps agonistes c-mpl qui jouent un rôle dans la réplication, la différenciation et la maturation de cellules sanguines et, notamment, de mégacaryocytes et de cellules progénitrices de mégacaryocytes. Ces composés peuvent être utilisés dans le traitement de la thrombocytopénie.

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