C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2424371
A modified antibody containing at least two H chain V domains and at least two L chain V domains of a monoclonal antibody which transduces a signal into cells by crosslinking a cell surface molecule to thereby serve as an agonist. Because of being usable as a signal transduction agonist, this modified antibody is useful as a preventive and/or a remedy etc. for various diseases such as caner, inflammation, dysendocrinism and blood diseases.
L'invention concerne un anticorps modifié contenant au moins deux domaines V de chaîne H et au moins deux domaines V de chaîne L d'un anticorps monoclonal, lequel transduit un signal dans des cellules par réticulation d'une molécule de surface cellulaire, de manière à agir en tant qu'agoniste. Etant donné que cet anticorps modifié peut être utilisé en tant qu'agoniste de transduction de signal, il est utile à titre préventif et/ou curatif dans diverses maladies telles que le cancer, l'inflammation, la dysendocrinie et les maladies du sang.
Fukushima Naoshi
Ohtomo Toshihiko
Tsuchiya Masayuki
Tsunoda Hiroyuki
Uno Shinsuke
Chugai Seiyaku Kabushiki Kaisha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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