C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2168110
Agonists and antagonists of human IL-10 are provided by this invention which are based upon modification of the termini of mature human IL-10. Also provided are compositions and methods for supplying or inhibiting the biological activity of human IL-10. Such compositions may be useful in the treatment of diseases characterized by inappropriate Th responses. Nucleic acids encoding the agonists and antagonists, recombinant vectors and transformed host cells comprising such nucleic acids, and methods for making the agonists and antagonists using the transformed host cells are also provided.
Agonistes et antagonistes d'interleukine-10 (IL-10) humaine obtenus par modification des terminaisons de l'IL-10 humaine mature. Des compositions et procédés destinés à provoquer ou à inhiber l'activité biologique d'IL-10 humaine sont également décrits. Lesdites compositions peuvent être utiles dans le traitement de maladies caractérisées par une réponse inappropriée des lymphocytes T auxiliaires. Des acides nucléiques codant lesdits agonistes et antagonistes, des vecteurs de recombinaison et des cellules hôtes transformées comportant lesdits acides nucléiques, ainsi que des procédés de production desdits agonistes et antagonistes à l'aide des cellules hôtes transformées sont en outre décrits.
Cai Xiao-Yan
Chou Chuan-Chu
Schering Corporation
Swabey Ogilvy Renault
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