Agonists and antagonists of the s1p5 receptor, and methods...

Details Agonists and antagonists of the s1p5 receptor, and methods... Agonists and antagonists of the s1p5 receptor, and methods...

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2749960

Disclosed are compounds that are agonists or antagonists of the S1P5 receptor, compositions comprising said compounds, and methods of using said compounds and compositions. In certain embodiments, said compounds are 1-benzylazetidine-3-carboxylic acid derivatives. In certain embodiments, said methods relate to the treatment of neuropatic pain and/or a neurodegenerative disorder. In certain embodiments, said compounds may be used in combination with a second therapeutic agent.

La présente invention concerne des composés qui sont des agonistes ou des antagonistes du récepteur S1P5, des compositions comprenant lesdits composés, et des procédés d'utilisation desdits composés et compositions. Dans certains modes de réalisation, lesdits composés sont des dérivés de l'acide 1-benzylazétidine-3-carboxylique. Dans certains modes de réalisation, lesdits procédés sont destinés à traiter une douleur neuropathique et/ou un trouble neurodégénératif. Dans certains modes de réalisation, lesdits composés peuvent être utilisés en association avec un second agent thérapeutique.

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