Agonists for antimicrobial peptide systems

A - Human Necessities – 23 – L

Patent

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Details

A23L 1/30 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2711807

Short chain fatty acids (SCFAs) and glycerol esters of SCFAs not previously used for that purpose are provided for use as a medicament for treating, preventing or counteracting microbial infections in animals, including humans, by stimulating the innate antimicrobial peptide defense system. Preferred compounds include phenyl substituted short chain fatty acids (SCFAs) derivatives and. Also provided are methods and compositions for treating, preventing or counteracting microbial infections, including bacterial, viral, fungal, and parasitic infections, by administration of medicaments comprising a secretagogue-effective amount of the compounds of the invention.

Des acides gras à chaîne courte (SCFA) et des esters de glycérol et de SCFA non précédemment utilisés dans ce but sont proposés pour une utilisation en tant que médicament pour traiter, prévenir ou agir à l'encontre d'infections microbiennes chez les animaux, comprenant les êtres humains, par la stimulation du système de défense peptidique antimicrobien inné. Les composés préférés comprennent des dérivés d'acides gras à chaîne courte substitués par phényle (SCFA). L'invention porte également sur des procédés et des compositions pour traiter, prévenir ou agir à l'encontre d'infections microbiennes, comprenant des infections bactériennes, virales, fongiques et parasitiques, par l'administration de médicaments comprenant une quantité efficace de sécrétagogue des composés de l'invention.

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