Agonists of follicle stimulating hormone activity

Details Agonists of follicle stimulating hormone activity Agonists of follicle stimulating hormone activity

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) C07D 277/14 (2006.01) C07D 277/20 (2006.01) C07D 417/02 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2425889

In one aspect, the present invention provides novel compounds. In addition, the invention provides a FSH receptor agonist, wherein the agonist binds to a FSH receptor having a FSH binding site and, wherein the agonist is noncompetitve with FSH for the FSH binding site. In another aspect, the invention provides methods of using the compounds of the present invention for diverse pharmaceutical applications including, for example, CNS antiischemic agents, agents with antipsychotic or other psychoactive properties, antimicrobial agents and mammalian fertility regulating agent.

Selon un premier mode de réalisation, l'invention concerne de nouveaux composés. L'invention concerne également un agoniste de récepteur d'hormone de stimulation de follicule (FSH), dans lequel l'agoniste se lie à un récepteur de FSH possédant un site de liaison de FSH, et dans lequel ledit agoniste n'entre pas en concurrence avec FSH pour le site de liaison de FSH. Selon un second mode de réalisation, l'invention concerne des méthodes d'utilisation desdits composés dans diverses applications pharmaceutiques, par exemple, des thérapies utilisant des agents anti-ischémiques CNS, des agents possédant des propriétés antipsychotiques ou psychoactives, des agents antimicrobiens, et un agent de régulation de la fertilité d'un mammifère.

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