Agonists or antagonists of cutaneous t cell-attracting...

Details Agonists or antagonists of cutaneous t cell-attracting... Agonists or antagonists of cutaneous t cell-attracting...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 17/00 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2356661

Agonists or antagonists of CTACK or Vic chemokines, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the CTACK or Vic chemokines are specifically capable of inducing movement of a skin cell subset. Moreover, matching of ligand with GPR2 receptor in mammals provides methods of use.

L'invention concerne des agonistes ou des antagonistes des chémokines CTACK ou Vic, ainsi que diverses méthodes d'utilisation dans des applications dermatologiques et apparentées. En particulier, la méthode utilise le fait que les chémokines CTACK ou Vic sont spécifiquement capables d'induire le mouvement d'un sous-ensemble de cellules de la peau. De plus, l'appariement du ligand au récepteur GPR2 chez des mammifères procure des méthodes d'utilisation.

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