A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2488725
Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding agouti-related protein (AgRP). AgRP deficient transgenic animals have a reduced day time respiratory quotient (RQ), indicating that AgRP is involved in the regulation of energy metabolism, resulting in the reduced usage of fat as an energy source. These AgRP deficient transgenic animals can be used to select for and test potential modulators of AgRP. This data allows for methods of screening for AgRP modulators which regulate energy metabolism and caloric utilization. The disclosure also relates to a NPY/AgRP double knockout mouse which can be used to select for and test potential modulators (e.g., agonists or antagonists) of AgRP and/or NPY.
L'invention concerne des cellules et des animaux transg~niques non humains modifi~s de manire ~ Útre d~ficients en gne codant la prot~ine li~e ~ l'agouti (AgRP). Les animaux transg~niques d~ficients en AgRP pr~sentent un quotient respiratoire journalier (RQ) r~duit, indiquant que l'AgRP est impliqu~ dans la r~gulation du m~tabolisme ~nerg~tique, r~sultant en une utilisation r~duite de graisse comme source d'~nergie. Ces animaux transg~niques d~ficients en AgRP peuvent Útre utilis~s en vue de s~lectionner et tester des modulateurs potentiels de l'AgRP. Ces donn~es sont utilis~es dans des proc~d~s de criblage de modulateurs d'AgRP qui r~gulent le m~tabolisme ~nerg~tique et l'utilisation calorique. Cette invention concerne ~galement une souris double knockout NPY/AgRP pouvant Útre utilis~e en vue de s~lectionner et de tester des modulateurs potentiels (par ex. des agonistes ou des antagonistes) d'AgRP et/ou NPY.
Chen Howard Y.
Metzger Joseph M.
Qian Su
Trumbauer Myrna E.
Van Der Ploeg Leonardus H. T.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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