Aids and sle prophylactics

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 14/16 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2168268

It is an object of the present invention to provide preparations for the treatment or prophylaxis of AIDS and systemic lupus erythematosus and related disorders. The invention is based on my discovery of the process triggered in the immune system by HIV which leads to AIDS. HIV has a specific mechanism to activate the immune system to allow it to replicate and this same immune activation leads to an autoimmune process which eventually leads to AIDS. The preparation for treatment comprises of novel synthesised peptides whose amino acid sequences are derived from a human protein called ezrin and are based on the following sequence: NH2ThrGluLysLysArgArgGluThrValGluArgGluLysGluCOOH. The mechanism of action of these peptides is that they switch off specific retrovirally induced immune responses by immunological tolerance.

L'invention concerne la production de préparations s'appliquant au traitement ou à la prophylaxie du SIDA et du lupus érythémateux aigu disséminé et des affections apparentées. L'invention est basée sur la découverte du processus déclenché dans le système immun par le VIH qui est à l'origine du SIDA. Le VIH possède un mécanisme spécifique qui active le système immun pour lui permettre de se répliquer, et cette même activation immune entraîne un processus auto-immun qui est éventuellement à l'origine du SIDA. La préparation s'appliquant au traitement comprend de nouveaux peptides synthétisés dont les séquences d'acides aminés sont dérivées d'une protéine humaine nommée ezrine et qui sont basés sur la séquence suivante: NH¿2?ThrGluLysLysArgArgGluThrValGluArgGluLysGluCOOH. Le mécanisme d'action de ces peptides fait qu'ils déclenchent des réponses immunes spécifiques, induites de manière rétrovirale, par une tolérance immunologique.

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